Liga MX Monterrey vs Morelia: Live stream, team news, kick-off time, & match preview Goal Last updated 1 year ago 02:07 1/6/18 FacebookTwitterRedditcopy Comments(0) Julio Cesar Aguilar Liga MX Monterrey v Morelia Morelia Monterrey Last season’s defeated finalists look to get 2018 started right when they host Monarcas at the Estadio BBVA Bancomer After Monterrey surprisingly fell short in the Liga MX final last month, the club begins the Clausura on Saturday with a home match against Morelia.The game at the Estadio BBVA Bancomer will be a playoff rematch, after Rayados took care of Monarcas in the Apertura semifinals by a 5-0 aggregate scoreline. Rayados dominated Liga MX in the Apertura, finishing the regular season in first place, and Antonio Mohamed’s side will be expected to finish right near the top once again in the Clausura. Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player Game Monterrey vs Morelia Date Saturday, January 6 Time 8:00 p.m. ET Stream (US only) fuboTV (7-day free trial) LIVE STREAM Watch Monterrey vs. Morelia live and On-Demand with fuboTV (7-day free trial)New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.SQUADS & TEAM NEWS Position Monterrey players Goalkeepers Gonzalez, Carrizo, Resendez Defenders Montes, Basanta, Sanchez, Portales, Vasquez, Alvarez, Vangioni, Velarde, Castillo, Medina, Juarez Midfielders Molina, Ortiz, Zavala, J. Gonzalez, Amaya, Sanchez, A. Gonzalez, Urretaviscaya, Hurtado Forwards Funes Mori, Pabon, Benitez, Villa, Cruz Mohamed’s side will have most of its key contributors back for the Clausura, with Neri Cardozo the most significant name to depart the club. The club’s most significant offseason acquisition was Jonathan Urretaviscaya, who arrives from Pachuca and will be expected to bolster the Rayados attack from a wide midfield position. Potential starting XI: Gonzalez; Basanta, Montes, Sanchez, Medina; Gonzalez, Molina, Urretaviscaya, Hurtado; Funes Mori, Pabon. Position Morelia players Goalkeepers Malagon, Urbina, Sosa Defenders Achilier, Loeschbor, Vegas, Valadez, Rodriguez, Chavez, Guzman Midfielders Meraz, Osuna, Rodríguez, Rocha, Millar, Valdes, Reyes, Cuero, Vilchis, Sepulveda, Zarate, Polo, Lezcano Forwards Sandoval, Ruidiaz, Ortiz, Sansores Monarcas return much of the same side from the Apertura, when they finished in fourth place and defeated Toluca in the Liguilla quarterfinals, before falling to Monterrey in the semifinal. Manager Roberto Hernandez will not have new signing Ray Sandoval available, as the Peruvian striker’s paperwork has not gone through yet following his move from Sporting Cristal in Peru.Potential starting XI: Sosa; Vegas, Rodriguez, Achilier, Guzman; Millar, Osuna; Lezcano, Valdes, Sepulveda; Ruidiaz.GAME PREVIEW Rayados were dealt a body blow in the Apertura final against city rivals Tigres, losing 2-1 at home in the second leg to fall to a heartbreaking 3-2 aggregate defeat. Mohamed’s side did pick up a consolation prize a couple weeks later, defeating Pachuca to lift the Copa MX, but the Argentine manager enters the Clausura under pressure to deliver the title that evaded his side last month. Monterrey is positioned well to start the season off on the right foot, facing a Morelia side that will not have forgotten the 4-0 defeat it suffered in the Apertura semifinal second leg at the Estadio BBVA Bancomer just a month ago. Rayados return nearly their entire squad from last season, including top scorer Aviles Hurtado. The Colombian will be looking to erase some painful memories in the Clausura, after his late penalty miss against Tigres cost his side an opportunity to take last month’s final into extra time. Morelia has also put a premium on continuity, returned most of the squad that finished fourth in the Apertura.As usual, Monarcas will be counting on Raul Ruidiaz to deliver the goals. The Peruvian netted 11 times for his side in the Apertura, easily leading the team in scoring.
Recommended for you Star Studded Stop in Dallas for #TeamTCI Baha Mar deal should not be secret Related Items:Jetblue, Portia smith, Premier’s North American Sales and Investment blitz, road trip, team tci, tourism Survey shows TCI beaches keep visitors coming Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 26 May 2015 – The Tourism Minister says she anticipates the road trip led by herself and Premier Rufus Ewing will lead to a significant spike in visitor arrivals by 2017, a boom in dive vacations in Grand Turk and a 30% increase in tourism for North and Middle Caicos. During the Chicago leg of the Premier’s North American Sales and Investment blitz; Hon Porsha Smith shared that the six cities in six days Team TCI tour was a valuable effort. The hotel, tourism, business, real estate, government, aviation and media professionals on the road trip returned Saturday on board a fully sold JetBlue flight from Boston’s Logan International Airport. Facebook Twitter Google+LinkedInPinterestWhatsApp
Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 28 May 2015 – North Caicos is the backdrop for a new children’s book released by Belmont native, Bradley Handfield; the fictional folk story is called ‘Auntie Fannie, Mattie and the Talking Potatoes’. “I hope that this book would help to open up the imagination of children, let them see that there is a life, a real world that can go on in their imaginations,” said Mr. Handfield.Handfield will on Tuesday host an official launch and book signing at the Gus Lightbourne Gym at 10am where the public is invited. Students will also attend to receive from a variety of sponsors their books, after hearing a reading of the children’s novel by its author, Bradley Handfield. Science Fair open to public viewing by noon Recommended for you PNP open North & Middle Caicos causeway in tribute Facebook Twitter Google+LinkedInPinterestWhatsApp Related Items:bradley handfield, children’s book, gus lightbourne gym, North caicos, reading, students New Government contracts mean new clinic for Kew in North Caicos
Inter Milan have condemned the fans who made racial taunts towards Napoli defender Kalidou Koulibaly claiming the club has represented integration, innovation, and progressiveness since the existenceThe Nerazzurri were actually founded after a split from Milan, who wanted to have only Italian and Swiss players.That is the origin of their full name, Internazionale, with their founding document describing them as “brothers of the world”Dal 9 marzo 1908 Inter vuol dire integrazione, accoglienza e futuro.Assieme alla nostra città lottiamo per un futuro senza discriminazioni.Chi non comprende la nostra storia, questa storia, non è con noi.#BrothersOfTheWorld #FCIM pic.twitter.com/OhoXdBjqLJ— Inter (@Inter) December 27, 2018“In response to the events that took place during Inter vs. Napoli on Wednesday evening and the consequent decision reached by the Lega Nazionale’s Sports Court for Serie A, the Club would like to reaffirm that since 9 March 1908, Inter has represented integration, hospitality and progressiveness,” the Beneamata wrote on their official website, with a shorter version on Twitter.“These characteristics have defined the history of Milan – a city that stands for inclusion and respect.Capello calls Lukaku “a modern striker” Manuel R. Medina – September 14, 2019 The former Italian manager believes Romelu Lukaku is perfectly suited for Antonio Conte’s Internazionale Milan in the Serie A.“Together with our city, we have always been fighting to help create a future free of discrimination. We are committed to promoting these values wherever we operate and they have always been a source of pride for the Club.Napoli boss Carlo Ancelotti said his team asked three times for their match at Inter Milan to be suspended because of alleged racist chanting, before a last-minute goal saw Inter win.https://t.co/fR7ojMC4eq pic.twitter.com/qAOViPCQ3J— BBC Sport (@BBCSport) December 26, 2018“Inter is present in 29 countries across the world, from Cambodia to Colombia, working with thousands of children involved in the Inter Campus project. The aim is to restore the right to play for those who are often in precarious circumstances – the importance of such activities has also been recognised by the United Nations.“From that night 110 years ago when our founders set us on our journey, we have always said no to any form of discrimination.“That is why we feel obliged today, once again, to reiterate that anyone who does not understand or accept our history – this Club’s history – is not one of us.”
“The essence there is to try to create a really compelling daily content snacking experience that leverages the breadth of our brands,” says Beagley. “We’re working on what content will be there and how it’s packaged, but we really want to make this into a compelling content experience for consumers using the SprintZone.”The deal, which has been several months in the making, will also include advertising and retail integration. When it comes to mobile advertising, Time Inc.’s mobile network of 20 million users, and Sprint’s targeted advertising service, Pinsight Media+, will be leveraged for collaboration, though specifics are still being worked out, Beagley says. “We want to collaborate to create new mobile advertising solutions for our respective customers and leverage the breadth of our networks,” adds Beagley. Beagley pointed to Time Amplify as one example where the company is already doing this. Time Amplify provides opportunities to maximize the sponsorship experience by including the advertiser’s message with Time Inc. content in a large format ad unit, which is then distributed on other third-party sites.Time Inc. already has a relationship with Apple’s iAd, which is built into the iOS operating system that powers iPhone, iPad, and iPod Touch, allowing brands to incorporate a variety of rich interactive experiences in an ad.“This additional relationship with Sprint will give us an opportunity to extend this even further across Android and Sprint devices,” says Beagely. Time Inc. will also provide content for Sprint’s retail stores—the device and network provider will use branded content to demonstrate the capabilities of their devices in-store.“There is a lot of work to be done here and different pieces will be moving at different speeds,” he says. “We certainly want to take this app opportunity to drive people to subscriptions, additional paid content offerings or paid apps, though we’ll have to figure out exactly how that flow works as we develop it with Sprint.”Stay updated on the latest FOLIO: news, follow us on Facebook & Twitter! Time Inc. is becoming evermore bullish in the mobile space—and a new strategic alliance with the Sprint Nextel Corp. will put its content front-and-center for millions of mobile users.“This is a deal with multiple prongs,” Cyrus Beagley, SVP and general manager of Time Inc.’s Advertising Sales & Marketing Group, tells FOLIO:. “There are three main pieces, and the first is content. We’re going to be working with Sprint over the next several months to create a customizable mobile app within the SprintZone, which comes pre-loaded on Sprint phones and will leverage our brands to provide the latest in entertainment, lifestyle, sports and business news.”The content within SprintZone will be updated in real time, pulling stories, photography and video from Time Inc. brands, with users able to customize their experience by brand.
WILMINGTON, MA — Thomas P. Coyne, Jr., age 69, of Wilmington, formerly of Charlestown, passed away unexpectedly at home on May 9, 2018.Tom was the beloved husband of Susan E. (Broderick) Coyne, devoted father of Matthew R. Coyne & wife Courtney of Burlington, Andrew T. Coyne & wife Chantal of Wilmington and Meghan F. Coyne of Wilmington. Loving “Pop Pop” of Abigail Alice, Aubrey Frances, Parker Thomas, and Emma Rose. Cherished son of the late Thomas P. and Margaret (Tagen) Coyne, dear brother of Margaret Crowley & husband David of Melrose and Stephen Coyne & wife Nancy of Salem, NH. Tom is also survived by his mother-in-law Frances Broderick of Norwood as well as many brothers and sisters-in-law, nieces and nephews.Thomas proudly served in the U. S. Navy.Family and friends will gather at the Nichols Funeral Home, 187 Middlesex Ave. (Rte. 62), Wilmington, on Monday, May 14th at 9:00 a.m. followed by a Mass of Christian Burial in St. Thomas of Villanova Church, 126 Middlesex Ave., Wilmington at 10:00 a.m. Interment with Military Honors will follow in Wildwood Cemetery, Wilmington. Visiting Hours will be held at the Funeral Home on Sunday, May 13th from 5:00-8:00 p.m.In lieu of flowers, donations in Thomas’ memory may be made to the Boston Children’s Hospital Trust, 401 Park Dr., Suite 602, Boston, MA 02215.(NOTE: The above obituary is from Nichols Funeral Home.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email email@example.com.Share this:TwitterFacebookLike this:Like Loading… RelatedOBITUARY: Lucille C. (Enos) Gilson, 77In “Obituaries”OBITUARY: Maureen F. (McKenna) McHugh, 80In “Obituaries”OBITUARY: Marie J. (Ciampa) Cummings, 81In “Obituaries”
Preview • 2019 Audi A7: Staying true to its swoopy hatchback form Audi 2018 Audi Q7: Rockin’ the suburbs More From Roadshow 2018 Audi S4: The sweet spot sport sedan Shanghai Motor Show 2019 Audi Enlarge ImageI don’t know if they’re for channeling air or what, but all those diamonds do look pretty crazy. Audi Last week, we got our first glimpse of Audi’s Shanghai-bound AI:me concept by way of some pencil sketches. Now, Audi has seen fit to show off a part of the real thing, and it’s wild.While the teaser sketches were plenty futuristic, Audi on Thursday unveiled a proper teaser showing off a front corner of the upcoming AI:me concept, which is slated to debut at the 2019 Shanghai Motor Show next week. While Audi’s current design language is definitely found in the headlight, both the headlight and the body surrounding it are covered in diamond-shaped dimples that look both really weird and really cool.The AI:me concept’s pod shape is evident in the teaser, as well. One character line starts at the headlight and forms a very broad shoulder across the length of the body, also acting as a meeting point for some very large glass panels. The wheels are contained within individual fenders that give the car a properly sci-fi shape. Then again, when it comes to pie-in-the-sky concepts, it should be a little odd. In addition to its wild design, there’s plenty of next-gen tech hidden away. It previews a Level 4 autonomous vehicle, with a spacious interior dedicated to comfort and, based on the previous teasers, a steering wheel that retracts into the dashboard.Audi’s Shanghai booth isn’t just about the future, though. The present will be accounted for, too. In addition to the AI:me concept, Audi will debut the Q2L e-tron, a stretched version of the small Q2 SUV that adds 1.3 inches to the body and packs an electric powertrain with an estimated range of about 165 miles. We’ll be on the ground in Shanghai next week, so keep your eyes peeled to Roadshow for more on these and other cars. Tags Audi’s Q2 taunts US with design, tech, lack of availability (pictures) 0 Share your voice Concept Cars Electric Cars More about 2019 Audi A7 2019 Audi Q8 review: Stop worrying and love the roof 46 Photos Post a comment Review • 2019 Audi A7 review: A powerhouse of luxury and tech
Worries over US trade policy have affected Asian markets [Representational image]ReutersAsian equities sagged on Friday as worries about U.S. trade policy hit global financial markets, which were already shaken this week by political turmoil in Italy.Wall Street shares posted deep losses overnight after the United States said it would impose tariffs on aluminum and steel imports from Canada, Mexico and the European Union.Fears of a global trade conflict, which had partially receded over the past few weeks, were rekindled as Washington’s allies took steps to retaliate against the U.S. measures.MSCI’s broadest index of Asia-Pacific shares outside Japan dipped 0.08 percent.The index was down roughly 0.9 percent this week, during which it touched a six-week low on concerns that political developments in Italy could weaken its commitment to the euro and exacerbate the country’s debt burden.Japan’s Nikkei .N225 shed 0.1 percent.”The downward correction in equity markets is likely to continue, as the United States has opened up a new point of contention on the trade front by getting involved with the European Union,” said Soichiro Monji, senior economist at Daiwa SB Investments in Tokyo.”President (Donald) Trump has not accomplished very much in terms of trade issues and is likely to remain vocal with the U.S. midterm elections coming up.”Investor focus on Friday is also on Chinese markets with the country’s mainland shares scheduled to join index publisher MSCI’s emerging market index. The inclusion was seen as potentially increasing investment from global investors into China’s capital markets.In currencies, the Canadian dollar and the Mexican peso were on the defensive, weighed by the U.S. decision to impose tariffs on aluminum and steel imports from these countries.The euro was little changed at $1.1687 holding to modest gains made on relief overnight as Italy’s anti-establishment parties reached a deal to resurrect their proposed coalition government.The deal by the Italian parties averted the prospect of a new snap election, which had rattled global markets earlier this week and sent the euro to a 10-month low of $1.1510 on Tuesday.The dollar was steady at 108.830 yen, having lost about 0.5 percent against this week as the earlier global market tumult had enhanced demand for the Japanese currency, which is a perceived safe-haven.Brent crude LCOc1 rose 0.2 percent to $77.73 a barrel.Prices swerved between $$74.49, a three-week low, to $78.75 this week on speculation towards output by major oil-producing nations.U.S. crude was down 0.1 percent at $66.97 a barrel CLOc1.Brent’s premium over U.S. crude reached its widest since March 2015 this week as a lack of pipeline capacity in the United States has trapped a lot of output inland.[Source- Reuters]
An innocent man has been languishing in jail reportedly for 3 years, for a crime committed by his elder brother in Sotobongram area of Rajshahi town, reports UNB.The victim was identified as Sajal Mia, younger brother of one Selim alias Fazal, who was convicted in a case filed under Women and Children Repression Prevention Act.Sajal’s lawyer filed an appeal with the Women and Children Repression Prevention Tribunal seeking release on 26 May.As per the case statement, Selim, the prime accused of the case has been on the run since the case was filed in 2001. Police has been searching for the convict since then but failed to trace him.After nine years, based on secret information that Selim visited his house, police conducted a drive there and picked up Sajal, mistaking him to be Selim.However, police claim that they have arrested the right person who is convicted to life-term imprisonment in the case.Meanwhile, Sajal’s lawyer submitted photocopies of national identity cards of four siblings of Sajal which were attested by the local ward councilor, their land documents, picture of Selim and other necessary papers in this regard.Sajal’s lawyer Mohan Kumar Saha said, “Police being motivated by my client’s rivals arrested a wrong person. We informed the court about the matter while the court set 11 June for hearing over the matter in presence of Sajal.”Officer-in-charge of Sadar police station SM Masud Parvez said the witnesses of the case identified the convict and they have also submitted affidavits in this regard.
To embed this piece of audio in your site, please use this code: 00:00 /01:08 Share Listen X Wikipedia CommonsTexas Supreme Court, AustinThe Texas Supreme Court is weighing whether to take up a lawsuit challenging existing term limits for Houston city officials.In 2015, Houston voters passed Proposition 2, changing the term limits for city officer holders from three two-year terms to two four-year terms. The question is whether most voters realized that the initiative actually extended, rather than limited, the length of time office holders could serve.“There were some voters I think that were confused that the people that were currently in office were grandfathered in,” Jon Taylor, a professor of political science at the University of Saint Thomas. Those grandfathered included nearly a third of the current Houston City Council.Attorney Eric Dick, who represents one of the plaintiffs, has asked the state Supreme Court to intervene. He wants the high court to order the city to hold new elections this November.“It is so rare whenever they’ve even humored hearing something bypassing the Court of Appeals,” Dick says. “The only time I know that they’ve done that before was with HERO [the Houston Equal Rights Ordinance], and we know how that turned out.”As the Texas Supreme Court considers whether to step in, it’s ordered Houston to file a response to Dick’s appeal no later than July 3. In a written statement, city officials said they plan to respond by the deadline.
Courtesy of OHSUThe first sign of successful in vitro fertilization, after co-injection of a gene-correcting enzyme and sperm from a donor with a genetic mutation known to cause hypertrophic cardiomyopathy.Scientists have been tinkering with the DNA in humans and other living things for decades. But one thing has long been considered off-limits: Modifying human DNA in any way that could be passed down for generations.Now, an international team of scientists reports they have successfully figured out a way to edit the DNA in human embryos — without introducing the harmful mutations that were a problem in previous attempts elsewhere. The work was published online Wednesday in the journal Nature.“It’s a pretty exciting piece of science,” says George Daley, dean of the Harvard Medical School, who was not involved in the research. “It’s a technical tour-de-force. It’s really remarkable.”The research is ultimately aimed at helping families plagued by genetic diseases. The new experiment used a powerful new gene-editing technique to correct a genetic defect behind a heart disorder that can cause seemingly healthy young people to suddenly die from heart failure.The experiment corrected the defect in nearly two-thirds of several dozen embryos, without causing potentially dangerous mutations elsewhere in the DNA.None of the embryos were used to try to create a baby. But if future experiments confirm the techniques are safe and effective, the scientists say the same approach could be used to prevent a long list of inheritable diseases.“Potentially, we’re talking about thousands of genes and thousands of patients,” says Paula Amato, an associate professor of obstetrics and gynecology at Oregon Health & Science University in Portland. She was a member of the scientific team from the U.S., China and South Korea.Other diseases that might ultimately benefit from such an approach include Huntington’s disease, Cystic fibrosis, perhaps an inherited form of Alzheimer’s disease and cases of breast and ovarian cancer caused by mutations in the BRCA genes.Nonetheless, the work is setting off alarm bells among critics around the world.“I think it’s extraordinarily disturbing,” says Marcy Darnovsky, who directs the Center for Genetics and Society, a genetics watchdog group in Berkeley, Calif. “It’s a flagrant disregard of calls for a broad societal consensus in decisions about a really momentous technology that could be used good, but in this case is being used in preparation for an extraordinarily risky application.”“If irresponsible scientists are not stopped, the world may soon be presented with a fait accompli of the first [genetically modified] baby,” says David King, who heads the U.K-based group Human Genetics Alert. “We call on governments and international organizations to wake up and pass an immediate global ban on creating cloned or GM babies, before it is too late.”Amato and others stress that their work is aimed at preventing terrible diseases, not creating genetically enhanced people. And they note that much more research is needed to confirm the technique is safe and effective before anyone tries to make a baby this way.But scientists hoping to continue the work in the U.S. face many regulatory obstacles. The National Institutes of Health will not fund any research involving human embryos (the new work was funded by Oregon Health & Science University). And the Food and Drug Administration is prohibited by Congress from considering any experiments that involve genetically modified human embryos.Nevertheless, the researchers say they’re hopeful about continuing the work, perhaps in Britain. The United Kingdom has permitted genetic experiments involving human embryos forbidden in the United States.“If other countries would be interested, we would be happy to work with their regulatory bodies,” says Shoukhrat Mitalipov, director of the Oregon Health & Science University’s Center for Embryonic Cell and Gene Therapy.One major concern is safety to a developing embryo — whether genetically modified human embryos would indeed produce healthy babies. But on a broader level, any changes made in the DNA of an embryo would be passed down for generations. That raises fears that any mistakes in the editing that inadvertently caused new diseases could become a permanent part of that family’s genetic blueprint.Darnovsky and others also worry that modifying human DNA in an embryo could give rise to “designer babies.” That’s when parents pick and choose the traits of their children to try to make them smarter, taller, stronger or have other traits that make them seem superior. That’s not yet technically possible. But critics fear scientists are already moving in that direction.“The scenario is that you would have fertility clinics advertising to people who wanted to engineer their future children so that they could be presented as ‘enhanced’ — as biologically better than everyone else,” Darnovsky says. “It’s not a world we want to build. It’s not a world we want to live in.”Unscrupulous researchers could also rush the technology into fertility clinics to try to start creating babies they can bill as genetically enhanced before the technology has even been proved safe, and before a societal consensus has been reached about what applications should be permitted.“This is a strong statement that we can do genome editing,” says Harvard’s Daley. “The question that remains is: ‘Should we?’ We need a deeper public discourse around the ethical implications of this technology.”Darnovsky and some scientists argue that many couples who carry genetic diseases already have safer alternatives to this sort of gene editing. Couples carrying genetic diseases can go through in vitro fertilization (IVF) and have their embryos tested before being implanted in the woman’s womb.“I will admit to experiencing a sense of puzzlement,” says Fyodor Urnov, an associate director at the Altius Institute for Biomedical Sciences, a nonprofit research institute in Seattle.“The question I have is: ‘Why did you folks bother, given that there is a safe, effective, approved and ethical way to attain exactly the goal you have set out to do without any of the significant logical and ethic hurdles of having to edit a human embryo?” Urnov says.Amato and the other scientists on the international team say their approach could offer an alternative for couples for whom those standard options won’t work or are less desirable. But they agree the work should only move forward with careful regulatory oversight to prevent abuse.“Anytime there’s a new technology there’s a potential for misuse. We have to acknowledge that,” Amato says. “Personally I don’t feel that’s a reason not to pursue the research if you think there’s a potential benefit that outweighs that risk. And I think if you can prevent serious disease in future generations, that makes it worthwhile to pursue this.”The advance was first reported last week in Technology Review, a magazine published by the Massachusetts Institute of Technology. But the details were withheld and the researchers did not elaborate until the scientific paper had finished being vetted by other scientists for publication in Nature.For their experiments, the scientists obtained sperm from a donor carrying a mutation for the heart disorder cardiomyopathy. They then used that sperm to fertilize dozens of eggs obtained from healthy women.At the same time as fertilization, the researchers injected a powerful, microscopic gene-editing tool known as CRISPR-Cas9. The new technique makes it much easier than previous approaches to make very precise changes in DNA.Several scientists likened the approach to doing surgery on fetuses when they are in the womb. But this takes that idea much further, and involves repairing damaged DNA at a molecular level in the womb.“This is nano-surgery,” says George Church, a prominent Harvard geneticist who also was not involved in the research. “You’re doing it with the finest possible scalpel.”The editing tool very accurately cut into a mutated gene known known as MYBPC3, which causes cardiomyopathy. To the researchers’ surprise, the cut triggered the embryos to repair the defective gene on their own. This is a process that had previously been unknown, the scientists say.“The most exciting moment was when we realized the mechanism of repair,” Amato says. “It was fixing itself.”The researchers then let the embryos develop for several days so they could analyze them to see how well the experiments worked. In one part of the experiments involving 58 embryos, the approach corrected the mutation in more than 70 percent of the embryos, the researchers reported.“The gene defect was corrected with high efficiency,” Amato says.In addition, a detailed genetic analysis of the embryos concluded that the gene editing had not caused safety problems.“I think this is a significant advance,” Church says. “This is important.”In 2015, Chinese scientists reported trying to edit the DNA of embryos for the first time, also using CRISPR-Cas9. But that experiment involved embryos that could never develop normally. And while those researchers did succeed in editing the targeted defect, it also produced unintended defects elsewhere in the embryos’ DNA.The scientists who conducted the new experiments say they think they avoided those problems by injecting CRISPR at the same time the eggs were being fertilized by sperm.“That was key,” Mitalipov says.Alta Charo, a bioethicist at the University of Wisconsin, dismissed concerns about the work leading to designer babies.“This is not the dawn of the era of the designer baby,” says Charo, who co-chaired a committee formed by the National Academies of Sciences and the National Academy of Medicine to determine whether such experiments should be permissible. The committee concluded earlier this year that gene-editing of human embryos could be allowed in rare cases when no other options are available — but only to treat diseases.“I do not think that the constant drum beat about the fear of designer baby is warranted, Charo says. “What this is, is a possible step toward being able to edit the DNA in human embryos that’s reliable and precise.”In the meantime, scientists in Britain have won approval to use CRISPR to edit the DNA in healthy human embryos to learn more about normal human development. A team in Sweden has started similar experiments.“I think this needs to be tightly regulated,” says Fredrik Lanner, a geneticist at the Karolinska Institute in Stockholm who is conducting those experiments. “This is very exciting. But it also could be a double-edged sword. So I think we really have to be extra cautious with this technology.”Copyright 2017 NPR. To see more, visit http://www.npr.org/. Share
Journal information: Earth and Planetary Science Letters Citation: Meteorite find may be ‘missing half’ of interstellar collision (2014, July 1) retrieved 18 August 2019 from https://phys.org/news/2014-07-meteorite-interstellar-collision.html For several years scientists have debated the reason behind a lull, then sudden resurgence of biodiversity on planet Earth a little over 500 million years ago—some suggest the resurgence was due to a sudden major increase in the number of meteorite impacts. The increase, theorists suggest, came about due to an impact between two asteroids, likely somewhere between Jupiter and Mars. Debris from the remains of one of those objects is believed to be the source of L chondrites, which have been found in many places around the globe. But, until now, no evidence of the other asteroid has been found on Earth, putting a damper on the theory—some have suggested the second asteroid simply vaporized on impact. The meteorite found in Sweden has reignited interest, however, because it’s possible it is a piece of that second asteroid (because it appears to have been part of the same meteor shower as the L chondrites), which if true, will add a lot of credence to the entire theory that seeks to explain the sudden resurgence of life during the early part of the Ordovician period.The meteorite was found by quarry workers three years ago—other meteorites have been found in the same quarry before, but all of them were L chondrites. It was different from the other’s, the researchers noted, after studying its crystals, but was in the same rock layer and dating in the lab, suggesting it arrived during the same time period as part of a wider meteor shower. While still in the same class of primitive achondrites as L chondrites, it’s not exactly the same because of small differences in its elemental composition. The team is hopeful that the finding suggests that others will be found, hopefully some that can offer more evidence of their origin.The unique meteorite has not been given an official name yet—for now it’s simply being referred to as the “mysterious object.” The Thorsberg quarry and the Mysterious Object. (A) Thorsberg quarry on June 15, 2013. The Österplana church is seen in the back. (B) The Mysterious Object from the Glaskarten 3 bed. The meteorite is 8 × 6.5 × 2 cm in size. It was found in the youngest quarried bed of the Thorsberg quarry, at the top of the section. Credit: Earth and Planetary Science Letters, Volume 400, 15 August 2014, Pages 145–152. Explore further Research shows collision created Chelyabinsk asteroid (Phys.org) —A team of researchers with members from the U.S., Sweden and Switzerland studying a meteorite found in a Swedish quarry is reporting that the rock is unlike anything else ever found. In their paper published in Earth and Planetary Science Letters, they suggest the meteorite might just be evidence of a collision between two asteroids millions of years ago. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More information: A fossil winonaite-like meteorite in Ordovician limestone: A piece of the impactor that broke up the L-chondrite parent body? Earth and Planetary Science Letters, Volume 400, 15 August 2014, Pages 145–152. www.sciencedirect.com/science/ … ii/S0012821X14003367AbstractAbout a quarter of all meteorites falling on Earth today originate from the breakup of the L-chondrite parent body ∼470 Ma ago, the largest documented breakup in the asteroid belt in the past ∼3 Ga. A window into the flux of meteorites to Earth shortly after this event comes from the recovery of about 100 fossil L chondrites (1–21 cm in diameter) in a quarry of mid-Ordovician limestone in southern Sweden. Here we report on the first non-L-chondritic meteorite from the quarry, an 8 cm large winonaite-related meteorite of a type not known among present-day meteorite falls and finds. The noble gas data for relict spinels recovered from the meteorite show that it may be a remnant of the body that hit and broke up the L-chondrite parent body, creating one of the major asteroid families in the asteroid belt. After two decades of systematic recovery of fossil meteorites and relict extraterrestrial spinel grains from marine limestone, it appears that the meteorite flux to Earth in the mid-Ordovician was very different from that of today. © 2014 Phys.org